کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2817127 | 1159968 | 2013 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Promoter polymorphisms of pri-miR-34b/c are associated with hepatocellular carcinoma Promoter polymorphisms of pri-miR-34b/c are associated with hepatocellular carcinoma](/preview/png/2817127.png)
• We studied the association of pri-miR-34b/c and TP53 polymorphisms with HCC.
• We could find the relation between the pri-miR-34b/c(T>C) polymorphisms and HCC risk.
• The pri-miR-34b/c(T>C) polymorphisms may contribute to development of HCC.
• However, both of the polymorphisms had no influence for survival of HCC patients.
BackgroundNumerous studies have focused on the association between miR-34 family members, which are direct p53 targets, and carcinogenesis of many cancers, including hepatocellular carcinoma (HCC). This study aimed to assess whether polymorphisms in the single-nucleotide polymorphism miR-34b/c T>C (rs4938723) and TP53 Arg72Pro (rs1042522) increase the risk of HCC and influence outcome in patients with HCC.Patients and methodsWe enrolled 157 HCC patients and 201 cancer-free control subjects from the Korean population. MicroRNA polymorphisms were genotyped using the polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method.ResultsWe found that the miR-34b/c TC + CC frequency was significantly higher in HCC patients than in controls (adjusted odds ratio [AOR]: 1.580; 95% confidence interval [CI]: 1.029–2.426). The miR-34b/c CC-TP53 Arg/Arg combination significantly increased the risk of HCC (AOR: 13.644; 95% CI: 1.451–128.301). The SNPs miR-34b/c T>C and TP53 Arg72Pro(G>C) had no influence on survival of HCC patients.ConclusionsOur findings suggest that loss of the T allele in miR-34b/c T>C, and the miR-34b/c CC-TP53 Arg/Arg combination increases the risk of HCC in the Korean population.
Figure optionsDownload high-quality image (46 K)Download as PowerPoint slide
Journal: Gene - Volume 524, Issue 2, 25 July 2013, Pages 156–160