کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2817626 1160001 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association of interleukin-(IL)10 haplotypes and serum IL-10 levels in the progression of childhood immune thrombocytopenic purpura
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Association of interleukin-(IL)10 haplotypes and serum IL-10 levels in the progression of childhood immune thrombocytopenic purpura
چکیده انگلیسی

Derangement of genetic and immunological factors seems to have a pivotal role in the pathophysiology of immune thrombocytopenic purpura (ITP). We investigated interleukin(IL)-10 genetically determined expression in children with an acute progression of ITP (n = 41) compared to young patients with chronic ITP (n = 44) and healthy controls (n = 60), and attempted to correlate IL-10 production with the course of the disease. We genotyped our study population for three single nucleotide polymorphisms at positions − 1082 (A/G), − 819 (C/T) and − 592 (C/A) in the promoter region of the IL-10 gene. IL-10 levels were measured by enzyme-linked immunoassay.The IL-10 production in our study population was significantly higher in patients carrying the GCC haplotype than those bearing ACC and ATA haplotypes (6.9 ± 1.5 vs 3.6 ± 0.8 vs 3.3 ± 0.3, p = 0.03). The serum concentration of IL-10 was significantly higher in patients with an acute course of their disease, who mainly carried the GCC haplotype (92%), compared to chronic subjects, bearing the non-GCC haplotypes, and controls [17 pg/mL (1.7–18) vs 3.5 pg/mL (0.6–11) vs 3 pg/mL (1–7), p < 0.01)]. Our findings show that patients carrying the GCC-high producer IL-10 haplotype have an acute development of ITP and that IL-10 levels might represent a useful predictive biomarker of the disease course.


► Immunogenetic heterogeneity of childhood immune thrombocytopenic purpura (ITP).
► interleukin-10 serum levels as a biomarker of clinical progression of childhood ITP.
► Role of interleukin-10 haplotypes in defining the course and prognosis of ITP.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 505, Issue 1, 15 August 2012, Pages 53–56
نویسندگان
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