کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2818142 1160034 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biochemistry and biology of the inducible multifunctional transcription factor TFII-I: 10 years later
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Biochemistry and biology of the inducible multifunctional transcription factor TFII-I: 10 years later
چکیده انگلیسی

Exactly twenty years ago TFII-I was discovered as a biochemical entity that was able to bind to and function via a core promoter element called the Initiator (Inr). Since then several different properties of this signal-induced multifunctional factor were discovered. Here I update these ever expanding functions of TFII-I--focusing primarily on the last ten years since the first review appeared in this journal.


► Here I discuss recently discovered properties of the transcription factor TFII-I.
► TFII-I family factors all have unique repeated domains.
► NMR structure of a TFII-I repeat domain is solved and shows a unique fold.
► TFII-I in important for promoter–enhancer communication.
► TFII-I is implicated in cancer, angiogenesis and neurocognitive development.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 492, Issue 1, 15 January 2012, Pages 32–41
نویسندگان
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