کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2818142 | 1160034 | 2012 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Biochemistry and biology of the inducible multifunctional transcription factor TFII-I: 10 years later Biochemistry and biology of the inducible multifunctional transcription factor TFII-I: 10 years later](/preview/png/2818142.png)
Exactly twenty years ago TFII-I was discovered as a biochemical entity that was able to bind to and function via a core promoter element called the Initiator (Inr). Since then several different properties of this signal-induced multifunctional factor were discovered. Here I update these ever expanding functions of TFII-I--focusing primarily on the last ten years since the first review appeared in this journal.
► Here I discuss recently discovered properties of the transcription factor TFII-I.
► TFII-I family factors all have unique repeated domains.
► NMR structure of a TFII-I repeat domain is solved and shows a unique fold.
► TFII-I in important for promoter–enhancer communication.
► TFII-I is implicated in cancer, angiogenesis and neurocognitive development.
Journal: Gene - Volume 492, Issue 1, 15 January 2012, Pages 32–41