کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2819292 | 1569912 | 2008 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Genome-wide linkage scan localizes the harlequin locus in the Great Dane to chromosome 9 Genome-wide linkage scan localizes the harlequin locus in the Great Dane to chromosome 9](/preview/png/2819292.png)
Harlequin is a coat pattern of the Great Dane characterized by ragged patches of full color on a white background. Harlequin patterning is a bigenic trait, resulting from the interaction of the merle allele of SILV, and a dominant modifier locus, H. Breeding data suggest that H is embryonic recessive lethal and that all harlequins are Hh. To identify linkage with the harlequin phenotype, 46 Great Danes from 5 pedigrees were genotyped for 280 microsatellite markers in a whole genome screen. One marker on the telomeric end of chromosome 9 was suggestive of linkage. Fine mapping of this region using additional microsatellite markers and 10 Great Danes from a sixth pedigree resulted in significant LOD scores for 2 markers. Reported herein is linkage mapping of the H locus to a 3.27 Mb region of chromosome 9 containing approximately 20 genes.
Journal: Gene - Volume 418, Issues 1–2, 15 July 2008, Pages 49–52