کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2827111 1162418 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
B-cell receptor signaling in the pathogenesis of lymphoid malignancies
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
B-cell receptor signaling in the pathogenesis of lymphoid malignancies
چکیده انگلیسی

B-cell receptor (BCR) signaling pathway plays a central role in B-lymphocyte development and initiation of humoral immunity. Recently, BCR signaling pathway has been shown as a major driver in the pathogenesis of B-cell malignancies. As a result, a vast array of BCR-associated kinases has emerged as rational therapeutic targets changing treatment paradigms in B cell malignancies. Based on high efficacy in early-stage clinical trials, there is rapid clinical development of inhibitors targeting BCR signaling pathway. Here, we describe the essential components of BCR signaling, their function in normal and pathogenic signaling and molecular effects of their inhibition in vitro and in vivo.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Blood Cells, Molecules, and Diseases - Volume 55, Issue 3, October 2015, Pages 255–265
نویسندگان
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