کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2827399 1162440 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gammopathy and B lymphocyte clonality in patients with Gaucher type I disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
Gammopathy and B lymphocyte clonality in patients with Gaucher type I disease
چکیده انگلیسی

IntroductionWe evaluated a novel approach for investigation of lymphocyte dysregulation in Gaucher patients by including determination of IgH and TCR gene rearrangements together with levels of immunoglobulins, natural autoantibodies as well as presence of monoclonal protein.Materials and methodsMeasurement of serum immunoglobulins, monoclonal immunoglobulins, selected autoantibodies, as well as analysis of immunoglobulin heavy chain and T cell receptor gene rearrangements.ResultsImmunoglobulin disorder was detected in 29.6% patients, 40.7% demonstrated presence of B cell clonality and 44.4% demonstrated presence of autoantibodies. In five patients in our series, the presence of IgH gene rearrangement was the only detectable indicator of B cell dysfunction. TCR gene rearrangements were not found in any of the patients.ConclusionBased on our results, we propose IgH gene rearrangements as a new biomarker for investigation of B cell dysfunction occurring as a complication of Gaucher disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Blood Cells, Molecules, and Diseases - Volume 50, Issue 3, March 2013, Pages 222–225
نویسندگان
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