کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2827549 | 1162451 | 2011 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Thrombolytic along with anti-platelet activity of crinumin, a protein constituent of Crinum asiaticum Thrombolytic along with anti-platelet activity of crinumin, a protein constituent of Crinum asiaticum](/preview/png/2827549.png)
Several anticoagulants, anti-platelet and thrombolytic medications are used for the treatment of thrombotic disorders. Anti-coagulants and anti-platelet agents prevent the formation of blood clots but do not dissolve existing clots, whereas thrombolytic agents are able to dissolve a clot but emboli can form even after successful treatment. Thus, none of them provide a permanent and complete solution. In this regard a single molecule that could both dissolve the clot and prevent the formation of new clots would be useful in the treatment of thrombotic diseases. Crinumin, a stable and active (in many adverse conditions) serine protease, shows plasmin-like fibrinolytic activity and inhibits platelet aggregation and P-selectin exposure, as established by photography, phase contrast microscopy, whole blood optical Lumi-aggregometry and flow cytometry. Crinumin could be an efficient and inexpensive therapeutic agent for the treatment and prevention of thromboembolic diseases.
► First report to explore the thrombolytic activity of crinumin.
► Crinumin has also a potential anti-platelet activity.
► May helpful to develop a multifunctional drug regarding the thrombus related diseases.
Journal: Blood Cells, Molecules, and Diseases - Volume 47, Issue 2, 15 August 2011, Pages 129–132