کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2828089 | 1162475 | 2008 | 5 صفحه PDF | دانلود رایگان |

Human cytomegalovirus (CMV) infection continues to be one of the most important and life threatening complications after allogeneic stem cell transplantation (SCT).The reconstitution of CMV-specific T cell responses after SCT has been demonstrated to be protective against the development of CMV disease.To improve T cell immunity against CMV in bone marrow transplant patients, different strategies were explored. On one hand, CMV-specific T cells can be selected from the donor, and can be transferred to the patient without any further in vitro expansion. On the other hand, CMV-specific T cells can be activated and expanded in vitro by stimulation with antigen presenting cells (APCs) loaded with specific proteins or peptides.Here, we review the therapeutic application of CMV-specific T cells to fight CMV infection.
Journal: Blood Cells, Molecules, and Diseases - Volume 40, Issue 1, January–February 2008, Pages 71–75