کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2828089 1162475 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CMV-specific T cell therapy
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
CMV-specific T cell therapy
چکیده انگلیسی

Human cytomegalovirus (CMV) infection continues to be one of the most important and life threatening complications after allogeneic stem cell transplantation (SCT).The reconstitution of CMV-specific T cell responses after SCT has been demonstrated to be protective against the development of CMV disease.To improve T cell immunity against CMV in bone marrow transplant patients, different strategies were explored. On one hand, CMV-specific T cells can be selected from the donor, and can be transferred to the patient without any further in vitro expansion. On the other hand, CMV-specific T cells can be activated and expanded in vitro by stimulation with antigen presenting cells (APCs) loaded with specific proteins or peptides.Here, we review the therapeutic application of CMV-specific T cells to fight CMV infection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Blood Cells, Molecules, and Diseases - Volume 40, Issue 1, January–February 2008, Pages 71–75
نویسندگان
, , ,