کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2828259 1162480 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
G6PD (AC)n and (CTT)n microsatellites in Mexican Mestizos with common G6PD African variants
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
G6PD (AC)n and (CTT)n microsatellites in Mexican Mestizos with common G6PD African variants
چکیده انگلیسی

Genotyping for the G6PD (AC)n and (CTT)n microsatellites in a sample of 58 Mexican Mestizos with common G6PD African variants was carried out. The second mutation that defines to the variants G6PD A− 202A/376G, G6PD Santamaria376G/542T and G6PD A− 376G/968C very probably occurred on G6PD A376G chromosomes with the compound haplotypes, intragenic silent polymorphisms and microsatellites, Pvu-II/Pst-I/Bcl-I/Nla-III/(AC)n/(CTT)n: +/+/−/+/166 bp/195 bp, −/+/−/+/166 bp/201 bp, and −/+/−/+/166 bp/204 bp respectively. The structure of the repeat sequences for the AC-166 bp allele in the 3 variants was (TA)5(AA)1(TA)9(CA)10 whereas the repeat sequences for the CTT-195 bp, CTT-201 bp and CTT-204 bp alleles were (CTT)11(ATT)6, (CTT)7(ATT)12 and (CTT)7(ATT)13 in the first, second and third variants respectively. Genotyping for the G6PD microsatellites can be a useful tool with several applications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Blood Cells, Molecules, and Diseases - Volume 38, Issue 3, May–June 2007, Pages 238–241
نویسندگان
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