کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2828347 1162489 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The complex between activated protein C and protein C inhibitor: A clinically useful indicator of aortic aneurysms?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
The complex between activated protein C and protein C inhibitor: A clinically useful indicator of aortic aneurysms?
چکیده انگلیسی

The concentration of the complex between activated protein C and the protein C inhibitor reflects the degree of activation of blood coagulation. A sandwich method has been devised that measures the complex concentration in blood plasma. A key feature of the method is that the catching monoclonal antibody recognizes a complex-dependent neoepitope in PCI, which is a prerequisite, since the concentration of uncomplexed PCI is ≈104-fold higher than that of the complex. In patients with atherosclerotic disease, those with aortic aneurysms exhibit a three-fold increase in complex concentration compared to that of normal subjects.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Blood Cells, Molecules, and Diseases - Volume 36, Issue 2, March–April 2006, Pages 118–121
نویسندگان
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