کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2828349 1162489 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Searching for hemostatic modifier genes affecting the phenotype of mice with very low levels of FVII
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
Searching for hemostatic modifier genes affecting the phenotype of mice with very low levels of FVII
چکیده انگلیسی
FVIItTA/− mice are heterozygous for the FVII− null allele and a gene-targeted allele expressing very low levels of FVII. Approximately half the FVIItTA/− in a mixed C57Bl/6:129x1/SVJ background survive much longer than mice in a C57Bl/6 background, suggesting that genetic background affects the survival of mice expressing very low levels of FVII. A lineage of long-term surviving FVIItTA/− mice in a predominantly C57Bl/6 background was generated by selecting 16 weeks or older FVIItTA/− males and breeding them with C57Bl/6 FVII+/− females. It is postulated that these mice maintain 129x1/SVJ alleles at putative hemostatic modifier loci necessary for the survival of mice expressing very low levels of FVII. A SNP genomic scan was performed on DNA from long-term surviving FVIItTA/− mice. The scan identified 8 regions enriched for 129x1/SVJ sequences that might contain putative hemostatic modifier genes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Blood Cells, Molecules, and Diseases - Volume 36, Issue 2, March–April 2006, Pages 131-134
نویسندگان
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