کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2828644 1162744 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evidence that the kinesin light chain domain contains tetratricopeptide repeat units
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
Evidence that the kinesin light chain domain contains tetratricopeptide repeat units
چکیده انگلیسی

Homology models were built for various length sequences of the kinesin-1 light chain (KLC) domain of Drosophila melanogaster and subjected to 200 ns of all-atom molecular dynamics. We also cloned, expressed and characterized these regions spectroscopically. Results confirm that KLC contains tetratricopeptide repeat units; a regular array of repeating 34-residue helix–loop–helix monomers. Experimental and computational evidence is provided confirming the stability and overall helicity of individual TPR repeats as well as individual TPR units incorporated into a multi-TPR structure.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Structural Biology - Volume 177, Issue 3, March 2012, Pages 602–612
نویسندگان
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