کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2829029 1162780 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structure of human Brn-5 transcription factor in complex with CRH gene promoter
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
Structure of human Brn-5 transcription factor in complex with CRH gene promoter
چکیده انگلیسی

The Brn-5 protein, highly expressed in human brain, belongs to the POU family; a class of transcription factors involved in a wide variety of biological processes ranging from programming of embryonic stem cells to cellular housekeeping. This functional diversity is conferred by two DNA-binding subdomains that can assume several configurations due to a bipartite arrangement of POU-specific (POUS) and POU-homeo (POUH) subdomains separated by a linker region. The crystal structure of human Brn-5 transcription factor in complex with corticotrophin-releasing hormone (CRH) gene promoter reveals an unexpected recognition mode of the protein to its cognate DNA. Moreover, the structure also shows the role of the linker in allowing diverse configurations that can be assumed by the two subdomains.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Structural Biology - Volume 167, Issue 2, August 2009, Pages 159–165
نویسندگان
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