کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2829511 1162811 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Micromechanical response of mineral and collagen phases in bone
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
Micromechanical response of mineral and collagen phases in bone
چکیده انگلیسی

We report the first simultaneous quantification of Young’s modulus in the separate material phases of bone: collagen and carbonated hydroxyapatite. High-energy X-ray scattering and in situ loading revealed macroscopic, mineral, and collagen Young’s moduli (90% confidence limit) for a canine fibula equaled 24.7(0.2) GPa, 38.2(0.5) GPa {for 00.4 and 43.6(1.4) GPa for 22.2}, and 18(1.2) GPa, respectively. The mineral contained compressive residual stresses on the order of −60 to −80 MPa before loading and had a stress enhancement (ratio of internal to applied stress) between 2.0 and 2.3. The diffraction peak width increased with increasing applied stress, mainly along the bone’s longitudinal direction, and peak widths returned to pre-deformation values when load was removed. In a second fibula section from the same animal, the mineral’s internal stress changed from −50 MPa (22.2 reflection) to −75 MPa (00.4) just after removal from formalin to −10 MPa after eight hours immersion in phosphate-buffered saline; the corresponding change in collagen D-spacing ΔD/D equaled 4.2 × 10−3.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Structural Biology - Volume 157, Issue 2, February 2007, Pages 365–370
نویسندگان
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