کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2829933 | 1163327 | 2010 | 5 صفحه PDF | دانلود رایگان |
YCF45 belongs to a family of proteins of unknown function usually located in the chloroplast of plants. Its highly conserved homologues were found in the genomes of several Trypanosoma and Leishmania species. HA3-tagging of the YCF45 protein with the start codon as annotated in the GeneDB revealed its cytosolic localization in the cultured procyclic stage of Trypanosoma brucei. However, when a more upstream located start codon was used in another HA3-tagged construct, the resulting protein was targeted to the mitochondrion. We propose that YCF45 was acquired by an ancestral trypanosomatid by horizontal gene transfer and in the absence of a plastid was re-targeted to the mitochondrion.
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Journal: Molecular and Biochemical Parasitology - Volume 173, Issue 1, September 2010, Pages 43–47