کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2830817 1163758 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased expression of IL-18 in the serum and islets of type 1 diabetics
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
Increased expression of IL-18 in the serum and islets of type 1 diabetics
چکیده انگلیسی


• We analyzed IL-18 levels in the plasma of juveniles with type 1 diabetes (T1D).
• Increased IL-18 expression, but not IL-18BP or IL-37, was found in T1D vs. control.
• Free IL-18 also determined to be significantly increased in T1D samples.
• IL-18 and IL-18BP positively correlated to HbA1c levels in type 1 diabetics.
• Significant increase in IL-18 protein expression in T1D human pancreatic islets.

Type 1 diabetes (T1D) is a chronic disease characterized by autoimmune-mediated destruction of pancreatic insulin-producing beta cells. Interleukin (IL)-18 is a pro-inflammatory cytokine implicated in the pathogenesis of a number of inflammatory diseases. Here, we analyzed IL-18 levels in the plasma of juveniles with T1D. Compared to control subjects, IL-18 levels were significantly elevated in patients with T1D. On the other hand, levels of IL-18 binding protein (IL-18BP) and IL-37, two negative regulators of IL-18 function, remained unchanged when comparing T1D to control samples. Notably, however, although IL-18BP levels were not elevated, IL-18 and IL-18BP were found to be positively correlated in type 1 diabetics. Even so, free, unbound IL-18 remained significantly increased in diabetic patients. Additionally, correlation studies also revealed that IL-18 and IL-18BP are positively correlated with HbA1c levels in T1D patients, suggesting a potential link between IL-18 and metabolic control in these patients. Finally, we observed a significant increase in IL-18 protein expression within human pancreatic islet specimens collected from type 1 diabetics. These results further expand our knowledge of the role of IL-18 in T1D, may give insight into common pathogenic mechanisms associated with metabolic control in both T1D and T2D, and suggest that targeting this cytokine may improve therapeutic outcomes for T1D patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 64, Issue 2, April 2015, Pages 306–312
نویسندگان
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