کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2831229 | 1570736 | 2011 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Fyn binds to and phosphorylates T cell immunoglobulin and mucin domain-1 (Tim-1) Fyn binds to and phosphorylates T cell immunoglobulin and mucin domain-1 (Tim-1)](/preview/png/2831229.png)
The gene encoding T cell immunoglobulin and mucin domain-1 (Tim-1) is linked to atopy and asthma susceptibility in mice and humans. Tim-1 is a transmembrane protein expressed on activated lymphocytes and appears to have a role as a co-stimulatory receptor in T cells. The protein has not been shown to have enzymatic activity but contains a site within its cytoplasmic tail predicted to be a target for tyrosine kinases. Here, we show that Tim-1 can associate with the kinase Fyn, a member of the Src family of tyrosine kinases. This association does not require Fyn's kinase activity and is independent of the phosphorylation of a conserved tyrosine present within the cytoplasmic tail of Tim-1. Fyn is necessary for phosphorylation of this tyrosine in Tim-1 and the phosphorylation of Tim-1 varies with the levels of Fyn present in cells. These data suggest a role for Fyn in the signaling downstream of Tim-1.
Journal: Molecular Immunology - Volume 48, Issues 12–13, July 2011, Pages 1424–1431