کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2831325 | 1163799 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of Cybr, a cytohesin binder and regulator, in CD4+ T-cell function and host immunity
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
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چکیده انگلیسی
Cytohesin binder and regulator (Cybr) is known to regulate leukocyte adhesion and migration. However, its function in T-cells is poorly understood. Here, we investigated the role of Cybr in CD4+ T-cell function and host immunity. Cybr inhibited p38 phosphorylation following CD4+ T-cell stimulation. Since p38 regulates the expression of T-box expressed in T-cells (T-bet) but not GATA binding protein 3 (GATA-3) in T-cells, Cybr decreased the expression of T-bet and IFN-γ in CD4+ T-cells. Moreover, we found that host immunity against Listeria infection and IFN-γ production in blood were significantly compromised in Cybr-overexpressing transgenic mice. In summary, our data suggest that Cybr represses the expression of T-bet and IFN-γ via an inhibition of p38 in T-cells and consequently reduces host resistance to bacterial infection in mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 46, Issue 16, October 2009, Pages 3218-3223
Journal: Molecular Immunology - Volume 46, Issue 16, October 2009, Pages 3218-3223
نویسندگان
Shu-Lin Chang, C. Lee-Tian Chang, Pei-Ing Huang, Mi-Hua Tao, Wen-Chin Yang,