کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2832299 1163834 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
C3b complexation diversifies naturally processed T cell epitopes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
C3b complexation diversifies naturally processed T cell epitopes
چکیده انگلیسی

In addition to its well-established role in innate immunity, the complement component C3 is of critical importance in modulating the humoral response. In this study, we examined the effect of C3b linkage to tetanus toxin (TeNT) in the production of antigenic peptides inside human APC. We purified HLA-DR associated peptides isolated either from TeNT or TeNT–C3b pulsed cells. This study revealed that TeNT–C3b derived antigenic peptides are different and more numerous than TeNT derived peptides. This increased production of antigenic peptides correlated with a C3b-induced TeNT modification of proteolysis. These findings argue in favour of a new role for C3b in the modulation of T cell epitope during antigen processing and presentation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 44, Issue 11, April 2007, Pages 2893–2899
نویسندگان
, , , , , ,