کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2832358 1163837 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression and role of CR1 and CR2 on B and T lymphocytes under physiological and autoimmune conditions
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
Expression and role of CR1 and CR2 on B and T lymphocytes under physiological and autoimmune conditions
چکیده انگلیسی

The involvement of complement in the development and regulation of antibody responses under both healthy and pathological conditions is known for long. Unravelling the molecular mechanisms underlying the events however is still in progress. This review focuses on the role of complement receptors CR1 (CD35) and CR2 (CD21) expressed on T and B cells. Alteration in the expression and function of these receptors may contribute to the initiation and maintenance of immune complex mediated autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. Recent data regarding complement receptor expression on T lymphocytes and on memory B cells are also discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 46, Issue 14, September 2009, Pages 2767–2773
نویسندگان
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