کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2832546 1570745 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pathogenic role of anti-C1q autoantibodies in the development of lupus nephritis—a hypothesis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
Pathogenic role of anti-C1q autoantibodies in the development of lupus nephritis—a hypothesis
چکیده انگلیسی

A substantial proportion of patients with systemic lupus erythematosus (SLE) develop renal inflammatory disease, so-called lupus nephritis (LN). LN is a severe complication of SLE which is strongly associated with the presence of autoantibodies against C1q, the first component of the complement system, and other self-antigens (i.e. against DNA and nucleosomes) as well. In this review, the authors focus on anti-C1q autoantibodies and interpret the available data in order to explain how LN may develop and how anti-C1q autoantibodies contribute to its pathogenesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 44, Issues 1–3, January 2007, Pages 133–138
نویسندگان
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