کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2832662 | 1163841 | 2008 | 4 صفحه PDF | دانلود رایگان |

The postulate is analyzed that single V-gene segments encode recognition of the allele-specific determinants (a) required for the restrictive response of the αβ TCR to peptide. The consequence of this is that the positively selected V-domain, Vα or Vβ, engages an allele-specific determinant (a) on one subunit or domain of the MHC-encoded restricting element. The entrained V-domain docks on an invariant determinant (i) on the complementing subunit or domain. Consequently, each functional V-domain expresses an anti-a site and an anti-i site, and all subunits or domains of MHC-encoded restricting elements express an a- and i-determinant.The evidence, both biological and structural, discussed here strongly supports this postulate which has far reaching consequences.
Journal: Molecular Immunology - Volume 45, Issue 11, June 2008, Pages 3264–3267