کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2832662 1163841 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
What does the T-cell receptor recognize when it docks on an MHC-encoded restricting element?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
What does the T-cell receptor recognize when it docks on an MHC-encoded restricting element?
چکیده انگلیسی

The postulate is analyzed that single V-gene segments encode recognition of the allele-specific determinants (a) required for the restrictive response of the αβ TCR to peptide. The consequence of this is that the positively selected V-domain, Vα or Vβ, engages an allele-specific determinant (a) on one subunit or domain of the MHC-encoded restricting element. The entrained V-domain docks on an invariant determinant (i) on the complementing subunit or domain. Consequently, each functional V-domain expresses an anti-a site and an anti-i site, and all subunits or domains of MHC-encoded restricting elements express an a- and i-determinant.The evidence, both biological and structural, discussed here strongly supports this postulate which has far reaching consequences.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 45, Issue 11, June 2008, Pages 3264–3267
نویسندگان
,