کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2833429 | 1163871 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The novel avian protein, AWAK, contains multiple domains with homology to protease inhibitory modules
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The novel avian protein, AWAK, contains multiple domains with homology to protease inhibitory modules The novel avian protein, AWAK, contains multiple domains with homology to protease inhibitory modules](/preview/png/2833429.png)
چکیده انگلیسی
We report the purification of a 3.5Â kDa peptide with antimicrobial activity from the mucosa and epithelial cells of chicken intestine. The peptide contains a pattern of cysteines characteristic of a whey acidic protein (WAP) domain and was identified as the carboxy terminal fragment of a novel 767 amino acid avian protein which has a proposed molecular weight of 81Â kDa. Using the conserved domain database (CDD) we identified this 81Â kDa protein to contain multiple amino acid motifs with homology to WAP domains and an amino acid motif with homology to a Kunitz proteinase inhibitor domain. We propose to call this avian protein AWAK (Avian WAP motif containing, Kunitz domain containing). The presence of WAP and Kunitz modules suggests that AWAK has proteinase inhibitor activity. RT-PCR analyses demonstrated expression of the AWAK gene in the chicken intestine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 43, Issue 4, February 2006, Pages 388-394
Journal: Molecular Immunology - Volume 43, Issue 4, February 2006, Pages 388-394
نویسندگان
Christopher J. Nile, Claire L. Townes, Barry H. Hirst, Judith Hall,