کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2834447 1164313 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inference of molecular homology and sequence alignment by direct optimization
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک بوم شناسی، تکامل، رفتار و سامانه شناسی
پیش نمایش صفحه اول مقاله
Inference of molecular homology and sequence alignment by direct optimization
چکیده انگلیسی

That homologies exist and can be recognized and discovered is of central importance to comparative and evolutionary biology. Traditionally, homology assessment for both molecular and morphological data has been treated as a two-step process involving the generation of a proposition of homology and then the evaluation of that hypothesis through the test of congruence in a phylogenetic analysis. An alternative phylogenetic method, direct optimization, combines these into a one-step process in which positional homology and cladograms are co-estimated simultaneously. Here we examine the use of the term “homology” as it is applied to molecular data, and critique the concept of molecular homology one must accept if cladograms are to be interpreted as phylogenetic estimates. The test of congruence alone cannot be used to determine homologous (historically identical) features, and character analysis and the proposition of primary homology hypotheses is the only procedure that can identify correspondences between features justified as retaining phylogenetic information. The practical ramifications for phylogenetic analysis, such as data exclusion and the interpretation of tree-like diagrams as phylogenies, are discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Phylogenetics and Evolution - Volume 56, Issue 1, July 2010, Pages 305–311
نویسندگان
, ,