کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2838472 1165015 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
RNA rewriting, recoding, and rewiring in human disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی پزشکی مولکولی
پیش نمایش صفحه اول مقاله
RNA rewriting, recoding, and rewiring in human disease
چکیده انگلیسی


• A-to-I editing increases transcriptome diversity through multiple mechanisms.
• Aberrant regulation of A-to-I editing promotes cancer and degenerative disease.
• The functional impact of many RNA editing sites is still not fully understood.
• Treatments reverting A-to-I editing may have great potential in several diseases.

ADAR (adenosine deAminase acting on RNA) editases catalyze the deamination of adenosine to inosine (A-to-I), a post-transcriptional modification that alters coding and non-coding RNA stability and function. ADAR editases such as ADAR1 have recently been shown to play a key role in normal stem cell maintenance. While ADAR mutations are associated with hereditary autoimmune diseases such as Aicardi–Goutières syndrome, ADAR copy-number alterations and editase activation have been associated with progression of a broad array of malignancies. In this review we discuss evidence linking aberrant A-to-I editing to cancer and other degenerative diseases, and the mechanisms that may be targeted by novel therapeutic strategies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 21, Issue 9, September 2015, Pages 549–559
نویسندگان
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