کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2838612 | 1165034 | 2013 | 4 صفحه PDF | دانلود رایگان |
• The universe of painful Na-channelopathies is expanding.
• Na-channel mutations cause common painful neuropathies as well as rare genetic pain disorders.
• Mutations of NaV1.8, as well as NaV1.7, can cause painful channelopathies.
The universe of painful Na-channelopathies – human disorders caused by mutations in voltage-gated sodium channels – has recently expanded in three dimensions. We now know that mutations of sodium channels cause not only rare genetic ‘model disorders’ such as inherited erythromelalgia and channelopathy-associated insensitivity to pain but also common painful neuropathies. We have learned that mutations of NaV1.8, as well as mutations of NaV1.7, can cause painful Na-channelopathies. Moreover, recent studies combining atomic level structural models and pharmacogenomics suggest that the goal of genomically guided pain therapy may not be unrealistic.
Journal: - Volume 19, Issue 7, July 2013, Pages 406–409