کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2838770 1165050 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Asthmatic airway hyperresponsiveness: the ants in the tree
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی پزشکی مولکولی
پیش نمایش صفحه اول مقاله
Asthmatic airway hyperresponsiveness: the ants in the tree
چکیده انگلیسی

Airways from asthmatics have a propensity to narrow excessively in response to spasmogens (i.e., contractile agonists), a feature called airway hyperresponsiveness (AHR). AHR is an important contributor to asthma symptoms because the degree of responsiveness dictates the amount of airway narrowing that occurs in response to inflammation-derived spasmogens produced endogenously following exposure to environmental triggers, such as allergens, viruses, or pollutants. The smooth muscle encircling the airways is responsible for responsiveness because it constricts the airway lumen when commanded to contract by spasmogens. However, whether AHR seen in asthmatics is due to stronger muscle is equivocal. In this opinion article, I propose that environmental triggers and other inflammatory molecules released during asthma attacks contribute to AHR by increasing muscle force.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 18, Issue 11, November 2012, Pages 627–633
نویسندگان
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