کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2841522 1165403 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Working harder to stay alive: Metabolic rate increases with age in Drosophila simulans but does not correlate with life span
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش حشره شناسی
پیش نمایش صفحه اول مقاله
Working harder to stay alive: Metabolic rate increases with age in Drosophila simulans but does not correlate with life span
چکیده انگلیسی

The hypothesis that metabolic rate is inversely correlated with life span has long been debated. Another area of controversy has been the relationship between metabolic rate and aging. In most molecular studies key aspects of cellular metabolism have been shown to decline with age. Less attention has been focused on metabolic rate as an organism ages. We studied the survival of three Drosophila simulans fly lines and measured whole organism metabolic rate, mitochondrial DNA copy number and walking speed. Metabolic rate as assayed by CO2 production did not correlate with median lifespan but increased by 0.43–1.14%/d. In contrast, mitochondrial DNA copy number decreased by 0.56–1.06%/d. Physical activity, as assayed by mean walking speed, did not change with age but was positively correlated with mitochondrial DNA copy number. One explanation for these data is that metabolic rate was increased, in the face of a reduced mitochondrial DNA copy number and capacity for oxidative metabolism, to maintain a constant bioenergetic demand (physical activity). Alternatively, metabolic rate may increase to provide energy for the repair of cellular damage or due to a shift in metabolic substrate use over time.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Insect Physiology - Volume 53, Issue 12, December 2007, Pages 1300–1306
نویسندگان
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