کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2842727 1571089 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prenatal heat stress reduces male anogenital distance at birth and adult testis size, which are rescued by concurrent maternal Artemisia absinthium consumption
ترجمه فارسی عنوان
استرس گرما قبل از زایمان، فاصله بین انزال مردان را در هنگام تولد و اندازه بیضه بالغ کاهش می دهد که با مصرف همزمان Artemisia absinthium مادر ذخیره می شود
کلمات کلیدی
استرس گرما قبل از تولد؛ فاصله آنومالی؛ تست؛ Artemisia absinthium
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• Artemisia absinthium consumption and heat stress increased fluid intake synergistically in gestating mice.
• In utero heat stress shortened birth anogenital distance in males but was mitigated by dam Artemisia absinthium consumption.
• Prenatal heat stress reduced adult testis size, which was alleviated when dams drank Artemisia absinthium versus water.
• Prenatal Artemisia absinthium exposure did not have any apparent deleterious effects on dams or pups.

Boars from sows with elevated plasma cortisol during pregnancy have shorter anogenital distance (AGD), a trait associated with subfertility. Since gestating sows often experience summer heat stress (HS), a mouse model was used to evaluate the effect of prenatal HS on AGD and fertility; efficacy of the heat stress-mitigating supplement Artemisia absinthium (AB) was also evaluated. Dams were treated from d 8–18 of gestation, residing in ambient temperatures from 0700 to 1900 h. From 1900 to 0700 h females were exposed to 34.13±0.27 °C (HS) with access to water (HSW; n=9), HS with access to a 1% w/v decoction of AB (HSA; n=9), 20.81±0.20 °C (thermal neutral; TN) with water (TNW; n=10) or TN with AB (TNA; n=10). Daily liquid consumption was measured from d 6–18, and tail temperature was recorded at 0700 and 1900 h from d 8–18. Progeny weight and AGD were recorded at birth and weaning. At maturity, males were mated to non-littermate females from each treatment; these females were euthanized after 16 d of TN gestation. Reproductive traits were compared among all male/female treatment combinations; testes were weighed. Average liquid intake differed among treatments with HS and AB animals drinking more (P<0.0004). A treatment by time interaction for tail temperature (P<0.001) was observed; HS increased tail temperature of HSA and HSW animals similarly compared to TNA and TNW. Treatment affected (P<0.01) male birth AGD (HSW shortest; P<0.07). At maturity, HSW males also had the smallest testes (P<0.02). However, we observed no differences in fertility (P>0.10). These data indicate that in utero HS decreases both male birth AGD and adult testis size, effects which maternal AB consumption mitigates.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Thermal Biology - Volume 57, April 2016, Pages 84–91
نویسندگان
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