Preparation, spectral characterization, cytotoxic and thermal studies of platinum (IV) thiohydrazone complexes

Platinum (IV) complexes of type [Pt(L)2Cl2] [where, L=benzaldehyde-N,N-diphenyl-N-thiohydrazone (L1), salicylaldehyde-N,N-diphenyl-N-thiohydrazone (L2), acetaphenone-N,N-diphenyl-N-thiohydrazone (L3) and cyclohexanone-N,N-diphenyl-N-thiohydrazone (L4)] have been synthesized. The thiohydrazones can exist as thione–thiol tautomer and coordinates as a bidentate N–S ligand. The ligands found to act in monobasic bidentate fashion. Analytical data reveals that metal to ligand stoichiometry is 1:2. The complexes have been characterized by elemental analysis, IR, mass, electronic, 1H NMR spectroscopic studies, and TG/DTA study. Various kinetic and thermodynamic parameters like order of reaction (n), activation energy (Ea), apparent activation entropy (S#) and heat of reaction (ΔH) have also been carried out for one complex. Cytotoxic study has also been carried out for one complex.