کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2843953 1571165 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Operant licking for intragastric sugar infusions: Differential reinforcing actions of glucose, sucrose and fructose in mice
ترجمه فارسی عنوان
لیپینگ اپراتور برای تزریق قند داخل معده: اقدامات تقویت کننده دیفرانسیل گلوکز، ساکارز و فروکتوز در موش
کلمات کلیدی
سنجش قند پس از دهان، تزریق داخل عضلانی، لیس زدن اپراتور، گلوکز
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
چکیده انگلیسی


• C57BL/6 mice licked a dry spout for intragastric glucose but not fructose infusions.
• They adjusted their dry licking to changes in glucose concentrations and sugar type.
• FVB mice also dry licked for glucose but not fructose infusions.
• Yet, intragastric fructose conditions flavor preferences in FVB mice.
• Operant dry licking reflects nutrient-specific post-oral reinforcement.

Intragastric (IG) flavor conditioning studies in rodents indicate that isocaloric sugar infusions differ in their reinforcing actions, with glucose and sucrose more potent than fructose. Here we determined if the sugars also differ in their ability to maintain operant self-administration by licking an empty spout for IG infusions. Food-restricted C57BL/6J mice were trained 1 h/day to lick a food-baited spout, which triggered IG infusions of 16% sucrose. In testing, the mice licked an empty spout, which triggered IG infusions of different sugars. Mice shifted from sucrose to 16% glucose increased dry licking, whereas mice shifted to 16% fructose rapidly reduced licking to low levels. Other mice shifted from sucrose to IG water reduced licking more slowly but reached the same low levels. Thus IG fructose, like water, is not reinforcing to hungry mice. The more rapid decline in licking induced by fructose may be due to the sugar's satiating effects. Further tests revealed that the Glucose mice increased their dry licking when shifted from 16% to 8% glucose, and reduced their dry licking when shifted to 32% glucose. This may reflect caloric regulation and/or differences in satiation. The Glucose mice did not maintain caloric intake when tested with different sugars. They self-infused less sugar when shifted from 16% glucose to 16% sucrose, and even more so when shifted to 16% fructose. Reduced sucrose self-administration may occur because the fructose component of the disaccharide reduces its reinforcing potency. FVB mice also reduced operant licking when tested with 16% fructose, yet learned to prefer a flavor paired with IG fructose. These data indicate that sugars differ substantially in their ability to support IG self-administration and flavor preference learning. The same post-oral reinforcement process appears to mediate operant licking and flavor learning, although flavor learning provides a more sensitive measure of sugar reinforcement.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 153, 1 January 2016, Pages 115–124
نویسندگان
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