کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2843961 1571163 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nicotinic modulation of hippocampal cell signaling and associated effects on learning and memory
ترجمه فارسی عنوان
مدولاسیون نیکوتینیک سیگنالینگ سلول هیپوکامپ و اثرات مرتبط با آن در یادگیری و حافظه
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
چکیده انگلیسی


• Different kinases regulate different LTP/synaptic plasticity processes.
• Nicotine alters both hippocampal plasticity and learning.
• Nicotine alters hippocampal cell signaling cascades.
• Hippocampal kinases are altered during the acute nicotine-induced enhancement of learning.

The hippocampus is a key brain structure involved in synaptic plasticity associated with long-term declarative memory formation. Importantly, nicotine and activation of nicotinic acetylcholine receptors (nAChRs) can alter hippocampal plasticity and these changes may occur through modulation of hippocampal kinases and transcription factors. Hippocampal kinases such as cAMP-dependent protein kinase (PKA), calcium/calmodulin-dependent protein kinases (CAMKs), extracellular signal-regulated kinases 1 and 2 (ERK1/2), and c-jun N-terminal kinase 1 (JNK1), and the transcription factor cAMP-response element-binding protein (CREB) that are activated either directly or indirectly by nicotine may modulate hippocampal plasticity and in parallel hippocampus-dependent learning and memory. Evidence suggests that nicotine may alter hippocampus-dependent learning by changing the time and magnitude of activation of kinases and transcription factors normally involved in learning and by recruiting additional cell signaling molecules. Understanding how nicotine alters learning and memory will advance basic understanding of the neural substrates of learning and aid in understanding mental disorders that involve cognitive and learning deficits.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 155, 1 March 2016, Pages 162–171
نویسندگان
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