کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2844595 1166351 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pathological behaviors provoked by dopamine agonist therapy of Parkinson's disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Pathological behaviors provoked by dopamine agonist therapy of Parkinson's disease
چکیده انگلیسی

The dopamine agonist medications, pramipexole and ropinirole, are commonly used to treat Parkinson's disease. These two drugs have a highly specific affinity for cerebral D3 receptors, known to be localized to the mesolimbic system. Herein is described a common side effect of these drugs, encountered in our routine clinical practice: pathological behaviors. This includes excessive gambling, hypersexuality, shopping, hyperphagia or obsessive hobbying, which may develop in up to 30% of people taking higher agonist doses. In contrast, treatment with the dopamine precursor, levodopa, in the absence of D3 agonist therapy very rarely provokes such behavioral syndromes. Although these agonist-induced behaviors have been called “impulse control disorders”, the problem is not simply loss of impulse control, but rather a novel obsessive–compulsion directed at one or a few behaviors, often taking on pathological proportions. This experience points to the dopamine D3 receptor as a potential therapeutic target for gambling, sex or other addictions occurring spontaneously in the general population.

Research highlights
► Dopamine agonists may provoke pathological behaviors.
► Gambling, hypersexuality & hyperphagia are among these common pathological behaviors.
► The offending agonists have high & specific affinity for D3 receptors.
► Might such pathological behaviors developing spontaneously respond to D3 inhibition?

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 104, Issue 1, 25 July 2011, Pages 168–172
نویسندگان
,