کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2844986 1166373 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dietary trans-fat combined with monosodium glutamate induces dyslipidemia and impairs spatial memory
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Dietary trans-fat combined with monosodium glutamate induces dyslipidemia and impairs spatial memory
چکیده انگلیسی

AimsRecent evidence suggests that intake of excessive dietary fat, particularly saturated fat and trans-hydrogenated oils (trans-fatty acids: TFA) can impair learning and memory. Central obesity, which can be induced by neonatal injections of monosodium Glutamate (MSG), also impairs learning and memory. To further clarify the effects of dietary fat and MSG, we treated C57BL/6 J mice with either a TFA-enriched diet, dietary MSG, or a combination of both and examined serum lipid profile and spatial memory compared to mice fed standard chow. Spatial learning was assessed at 6, 16 and 32 weeks of age in a Morris Water Maze (MWM). The subjects were given four days of training to find a hidden platform and a fifth day of reversal learning, in which the platform was moved to a new location.ResultsThe TFA + MSG combination caused a central adiposity that was accompanied by impairment in locating the hidden platform in the MWM. Females in the TFA + MSG group showed a greater impairment compared to the other diet groups, and also showed elevated levels of fasting serum LDL-C and T-CHOL:HDL-C ratio, together with the lowest levels of HDL-C. Similarly, males in the TFA + MSG diet group were less successful than control mice at locating the hidden platform and had the highest level of abdominal adiposity and elevated levels of fasting serum LDL-C.ConclusionDietary trans-fat combined with MSG increased central adiposity, promoted dyslipidemia and impaired spatial learning.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 99, Issue 3, 3 March 2010, Pages 334–342
نویسندگان
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