Short-term effects of a novel fat emulsion on appetite and food intake

The objective of the study was to confirm the satiety/energy intake effect of a novel fat emulsion (Olibra®) versus placebo in the short term. A randomized, double-blind, placebo-controlled, crossover design was used. 41 subjects participated in the study (n = 21: junior-normal weight: age 23.7 ± 2.8 years; BMI: 22.0 ± 1.6 kg/m2; n = 20: senior-overweight: age 43.6 ± 4.9 years; BMI: 27.7 ± 1.6 kg/m2). An energy intake and satiety test (with questionnaires) took place on 2 occasions, with placebo or test yoghurt as breakfast. In the junior-normal weight subjects, consumption of test yoghurt reduced hunger and desire to eat during the morning (area under curve, p < 0.05) and increased the time elapsed between consumption of the yoghurt and the point at which hunger scores returned to baseline; 234 ± 79 min in the test condition compared to 174 ± 58 min in the placebo condition (p < 0.05). No significant differences in appetite scores between the test and placebo yoghurt were seen for the senior-overweight subjects. No effect on energy intake was seen in the total group, in the junior-normal weight and senior-overweight subjects. In conclusion, the Olibra® emulsion exerted a suppressive effect on the area under the curve of appetite ratings over 3 h in normal weight women aged 18 to 30 years. The Olibra® emulsion did not affect subsequent energy intake in either group.