کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2845862 1166402 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Topiramate attenuates the stress-induced increase in alcohol consumption and preference in male C57BL/6J mice
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Topiramate attenuates the stress-induced increase in alcohol consumption and preference in male C57BL/6J mice
چکیده انگلیسی

Stress increases the risk for alcohol abuse and relapse behaviors. However, there are hardly any medications to counteract stress-induced alcoholism and relapse behaviors. The present study examined the effects of topiramate (intraperitoneal injections of 10, 20, and 30mg/kg) in its ability to attenuate alcohol consumption on exposure to restraint stress in C57BL/6J mice on a 2-choice test procedure. Mice were either restrained for 1h/day for 5 successive days or left unrestrained. Subsequently, the effects of topiramate were studied in post-restraint days. Results showed that restrained animals increased alcohol consumption and alcohol preference significantly compared to control group on day 5. On post-restraint days, topiramate reduced alcohol consumption and alcohol preference on days 2–5 compared to saline. This experiment suggests that one mechanism of topiramate in reducing alcohol consumption and alcohol preference may involve an interaction with stress.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 96, Issue 1, 8 January 2009, Pages 189–193
نویسندگان
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