کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2846048 1166408 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Energy balance and hypothalamic effects of a high-protein/low-carbohydrate diet
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Energy balance and hypothalamic effects of a high-protein/low-carbohydrate diet
چکیده انگلیسی

Diets high in fat or protein and extremely low in carbohydrate are frequently reported to result in weight loss in humans. We previously reported that rats maintained on a low-carbohydrate–high fat diet (LC–HF) consumed similar kcals/day as chow (CH)-fed rats and did not differ in body weight after 7 weeks. LC–HF rats had a 45% decrease in POMC expression in the ARC, decreased plasma insulin, and increased plasma leptin and ghrelin. In the present study we assessed the effects of a low-carbohydrate–high-protein diet (HP: 30% fat, 65% protein, and 5% CHO) on body weight, caloric intake, plasma hormone levels and hypothalamic gene expression. Male rats (n = 16) were maintained on CH or HP for 4 weeks. HP rats gained significantly less weight than CH rats (73.4 +/− 9.4 and 125.0 +/− 8.2 g) and consumed significantly less kcals/day (94.8 +/− 1.5 and 123.6 +/− 1.1). Insulin was significantly reduced in HP rats (HP: 1.8 +/− 0.6 vs. CH: 4.12 +/− 0.8 ng/ml), there were no differences between groups in plasma leptin and plasma ghrelin was significantly elevated in HP rats (HP: 127.5 +/− 45 vs. CH: 76.9 +/− 8 pg/ml). Maintenance on HP resulted in significantly increased ARC POMC (HP: 121 +/− 10.0 vs. 100 +/− 5.9) and DMH NPY (HP: 297 +/− 82.1 vs. CH: 100 +/− 37.7) expression compared to CH controls. These data suggest that the macronutrient content of diets differentially influences hypothalamic gene expression in ways that can affect overall intake.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 92, Issue 3, 22 October 2007, Pages 454–460
نویسندگان
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