کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2846837 | 1571314 | 2015 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulation of epithelial sodium channel expression by oestradiol and progestogen in alveolar epithelial cells
ترجمه فارسی عنوان
مقررات بیان کانال سدیم اپیتلیال توسط ادرادیل و پروژستروژن در سلول های اپیتلیال آلوئولار
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کلمات کلیدی
NADPSGK1ARDS11β-hydroxysteroid dehydrogenase11β-HSD111β-HSD11β-hydroxysteroid dehydrogenase type 1CBX11β-Hydroxysteroid dehydrogenase type 2ENA11β-hsd2RT-PCRACTHHSDAFCRDSW/D - W / DAcute lung injury - آسیب ریه حادoestradiol - استراستالOestrogen - استروژنAli - اماinterleukin - اینترلوکینalveolar fluid clearance - ترخیص مایعات آلوئولارRespiratory distress syndrome - سندرم دیسترس تنفسیAcute respiratory distress syndrome - سندرم دیسترس تنفسی حادNAD - نادانnicotinamide adenine dinucleotide phosphate - نیکوتین آمید adenine dinucleotide phosphateNAD, nicotinamide adenine dinucleotide - نیکوتینامید آدنین دینوکلئوتیدadrenocorticotropic hormone - هورمون adrenocorticotropichydroxysteroid dehydrogenase - هیدروکسیستروئید دهیدروژنازreverse transcription-polymerase chain reaction - واکنش زنجیره ای رونویسی-پلیمراز معکوسProgestogen - پروژستروژنcarbenoxolone - کاربن اکسولونEpithelial Na+ channel - کانال نیکل Epithelial +glucocorticoid receptor - گیرنده گلوکوکورتیکوئید
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
چکیده انگلیسی
Oestrogen (E) and progestogen (P) exert regulatory effects on the epithelial Na+ channel (ENaC) in the kidneys and the colon. However, the effects of E and P on the ENaC and on alveolar fluid clearance (AFC) remain unclear, and the mechanisms of action of these hormones are unknown. In this study, we showed that E and/or P administration increased AFC by more than 25% and increased the expression of the α and γ subunits of ENaC by approximately 35% in rats subjected to oleic acid-induced acute lung injury (ALI). A similar effect was observed in the dexamethasone-treated group. Furthermore, E and/or P treatment inhibited 11β-hydroxysteroid dehydrogenase (HSD) type 2 (11β-HSD2) activity, increased corticosterone expression and decreased the serum adrenocorticotrophic hormone (ACTH) levels. These effects were similar to those observed following treatment with carbenoxolone (CBX), a nonspecific HSD inhibitor. Further investigation showed that CBX further significantly increased AFC and α-ENaC expression after treatment with a low dose of E and/or P. In vitro, E or P alone inhibited 11β-HSD2 activity in a dose-dependent manner and increased α-ENaC expression by at least 50%, and E combined with P increased α-ENaC expression by more than 80%. Thus, E and P may augment the expression of α-ENaC, enhance AFC, attenuate pulmonary oedema by inhibiting 11β-HSD2 activity, and increase the active glucocorticoid levels in vivo and in vitro.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 216, 15 September 2015, Pages 52-62
Journal: Respiratory Physiology & Neurobiology - Volume 216, 15 September 2015, Pages 52-62
نویسندگان
Ling Luo, Jia Deng, Dao-xin Wang, Jing He, Wang Deng,