کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2846911 1571326 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neural drive to respiratory muscles in the spontaneously breathing rat pup
ترجمه فارسی عنوان
در حال حرکت عضلانی به عضلات تنفسی در موشهای تنه ای خود به خودی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
چکیده انگلیسی


• A novel experimental approach for use in vivo in rodent pups <10 days of age.
• Useful for distinguishing augmented breaths from central apneas and from hypopneas.
• And for determining the distribution of central neural drive to upper airway and respiratory pump muscle motoneurons in room air and following environmental perturbation.

The neonatal rodent serves as useful and appropriate model within which to study respiratory system development. Despite an extensive literature that documents respiratory control in vitro, in vivo studies have relied upon whole body plethysmography to determine measures of respiratory frequency and tidal volume. However, plethysmography restricts access to the animal and thus, respiratory muscle electromyographic (EMG) activities have not been recorded in these studies previously. Electromyography yields accurate information about neural respiratory center output to the musculature and therefore, about the control of breathing in the intact animal. In this case, we documented neural drive to respiratory pump and upper airway muscles, electrocardiogram (ECG) and chest wall motions in rat pups up to 10 days of age noting sighs, spontaneous central apneas and hypopneas in room air and with successive increments in fractional inspired CO2 (FICO2). Our findings underscore the advantages of EMG recordings for purposes of determining the magnitude and distribution of neural drive to respiratory muscles and for characterizing the full range of breathing behaviors exhibited by rats in the early postnatal period.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 202, 1 October 2014, Pages 64–70
نویسندگان
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