کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2847221 1167343 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influence of parenchymal heterogeneity on airway-parenchymal interdependence
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Influence of parenchymal heterogeneity on airway-parenchymal interdependence
چکیده انگلیسی


• Tissue forces around a contracting airway depend on how the parenchymal is modeled.
• Random tissue heterogeneities do not affect airway-parenchymal interdependence.
• Lines of scar tissue increase parenchymal forces leading away from a contracting airway.

To estimate the influence of parenchymal heterogeneities on airway-parenchymal interdependence, we considered a circular airway embedded within elastic parenchyma modeled as (1) a hexagonal spring network, (2) a triangular spring network, or (3) a continuum. The deformation in the parenchyma due to active airway contraction was simulated using the finite element method. Random perturbations of elastic moduli in the parenchyma did not significantly affect the overall pattern of force transmission. By contrast, when elastic moduli were increased along a path projecting radially outward from the airway, the hexagonal spring network model predicted significantly increased force along this line as the airway contracted, but this was not observed in other two models. These results indicate that tissue heterogeneities generally have minimal effect on the global nature of airway-parenchymal interdependence. However, in the exceptional circumstance of scar tissue aligned radially from the airway wall, parenchymal distortion forces may propagate much farther from the airway wall than was previously thought.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 188, Issue 2, 15 August 2013, Pages 94–101
نویسندگان
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