کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2847244 1167344 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Quantifying parenchymal tethering in a finite element simulation of a human lung slice under bronchoconstriction
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Quantifying parenchymal tethering in a finite element simulation of a human lung slice under bronchoconstriction
چکیده انگلیسی

Airway hyper-responsiveness (AHR), a hallmark of asthma, is a highly complex phenomenon characterised by multiple processes manifesting over a large range of length and time scales. Multiscale computational models have been derived to embody the experimental understanding of AHR. While current models differ in their derivation, a common assumption is that the increase in parenchymal tethering pressure Pteth during airway constriction can be described using the model proposed by Lai-Fook (1979), which is based on intact lung experimental data for elastic moduli over a range of inflation pressures. Here we reexamine this relationship for consistency with a nonlinear elastic material law that has been parameterised to the pressure–volume behaviour of the intact lung. We show that the nonlinear law and Lai-Fook's relationship are consistent for small constrictions, but diverge when the constriction becomes large.

Comparison of parenchymal tethering pressure calculated using the Lai-Fook whole lung intact tissue approximation and using nonlinear elastic material law.Figure optionsDownload as PowerPoint slideHighlights
► Nonlinear elastic material laws (NLEML) were used to model lung slice with “airway”.
► Cauchy stress resulting from constriction of the adventitial radius was simulated.
► Results compared to Lai-Fook (LF) approximation for Pteth.
► NLEML agrees with LF in linear regime, predicts stronger Pteth at large constrictions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 183, Issue 2, 15 August 2012, Pages 85–90
نویسندگان
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