کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2847336 | 1167353 | 2012 | 7 صفحه PDF | دانلود رایگان |

Measures of respiratory variability including cardioventilatory coupling (CVC), were examined in 8 Down syndrome (DS), 4 Prader Willi syndrome (PWS) and 42 non-syndromic children (median age 7 years) referred for diagnostic polysomnography. Inspiratory onsets (I) and corresponding ECG R waves were determined, I–I, R–R and R–I intervals derived, and ventilatory frequency (f), standard deviation of f (SDf), coefficient of variation of f (CVf), median I–I and kurtosis and skewness I–I calculated. Proportional Shannon Entropy of the RI−1 interval (SHα) was measured to quantitate CVC. SHα varied with age (p = 0.02), oxygen saturation (p < 0.05) and PWS diagnosis (p = 0.001) in Stage 4 but not REM sleep. SDf and CVf varied with sleep state (p < 0.00001) as did kurtosis I–I (p < 0.0001) and skewness I–I (p = 0.004). Ventilatory frequency decreased with age in REM sleep (p = 0.03) and increased in obese children in REM (p = 0.02) and Stage 4 sleep (p = 0.004). Sleep state influences respiratory variability in children and CVC may confer a physiological advantage in children with PWS.
► Cardioventilatory coupling (CVC) occurs in children in REM and NREM sleep.
► CVC is more commonly seen with increasing age in Stage 4 sleep.
► Prader Willi syndrome subjects exhibit more CVC in Stage 4 sleep than other children.
► CVC is associated with higher oxygen saturation in Stage 4 sleep.
Journal: Respiratory Physiology & Neurobiology - Volume 181, Issue 1, 15 April 2012, Pages 1–7