کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2847449 | 1167366 | 2011 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Beneficial effects of early (but not late) intervention of heme oxygenase-1 on bleomycin-induced pulmonary fibrosis in mice Beneficial effects of early (but not late) intervention of heme oxygenase-1 on bleomycin-induced pulmonary fibrosis in mice](/preview/png/2847449.png)
The aim of this study is to explore the effects of early and late intervention in heme oxygenase-1 (HO-1) expression or activity on pulmonary fibrosis in mice. Mice were divided into four groups: one control and three bleomycin hydrochloride-induced groups in which mice were administered phosphate-buffered saline (PBS), hemin or Cr (III) mesoporphyrin IX chloride (CrMP). Early intervention with hemin, an HO-1 inducer, abrogated bleomycin-induced pulmonary fibrosis (fibrotic/reparative score decrease from 21.0 ± 2.4 to 13.8 ± 1.7, P < 0.01), and early intervention with CrMP, an HO-1 inhibitor, worsened bleomycin-induced pulmonary fibrosis (fibrotic/reparative score increase from 21.0 ± 2.4 to 32.5 ± 2.9, P < 0.01). Elevated glutathione expression and reduced expression of TGF-β1, hydroxyproline, LDH and MDA were seen in the lungs of the early hemin intervention group compared to that seen in the PBS group (P < 0.05). These results taken together show that HO-1 can prevent or ameliorate pulmonary fibrosis and oxidative stress and inflammation at an early stage of pulmonary fibrosis.
Journal: Respiratory Physiology & Neurobiology - Volume 175, Issue 2, 15 February 2011, Pages 239–246