کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2847922 1167396 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chronic hypoxia suppresses the CO2 response of solitary complex (SC) neurons from rats
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Chronic hypoxia suppresses the CO2 response of solitary complex (SC) neurons from rats
چکیده انگلیسی

We studied the effect of chronic hypobaric hypoxia (CHx; 10–11% O2) on the response to hypercapnia (15% CO2) of individual solitary complex (SC) neurons from adult rats. We simultaneously measured the intracellular pH and firing rate responses to hypercapnia of SC neurons in superfused medullary slices from control and CHx-adapted adult rats using the blind whole cell patch clamp technique and fluorescence imaging microscopy. We found that CHx caused the percentage of SC neurons inhibited by hypercapnia to significantly increase from about 10% up to about 30%, but did not significantly alter the percentage of SC neurons activated by hypercapnia (50% in control vs. 35% in CHx). Further, the magnitudes of the responses of SC neurons from control rats (chemosensitivity index for activated neurons of 166 ± 11% and for inhibited neurons of 45 ± 15%) were the same in SC neurons from CHx-adapted rats. This plasticity induced in chemosensitive SC neurons by CHx appears to involve intrinsic changes in neuronal properties since they were the same in synaptic blockade medium.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 168, Issue 3, 30 September 2009, Pages 272–280
نویسندگان
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