کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2847973 1167398 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of respiratory system impedance in the difference of ventilatory control between children and adults
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Role of respiratory system impedance in the difference of ventilatory control between children and adults
چکیده انگلیسی

How children are able to adapt their ventilation to the intensity of exercise faster than adults remain unclear. We hypothesized that differences of V˙E observed between children and adults depend on either peripheral chemoreceptors or central command activity. We examined ventilatory control parameters in either normoxic or hypoxic condition (FIO2=0.15FIO2=0.15). We analyzed the adaptability of the respiratory exchanges by (i) the measurement of ventilatory kinetics time-constant and (ii) the central command by the mouth-occlusion pressure (P0.1). A group of nine pre-pubescent children (mean age 9.5 ± 1 years) and a group of eight adults (mean age 24 ± 3.1 years) performed a constant-load exercise. In normoxia, children had significantly shorter time-constant (τ  ) V˙CO2 (respectively, 38.5 ± 4.3 and 53.1 ± 5.3 s; P < 0.001), τ  V˙E (respectively, 52.5 ± 13.1 s vs. 66.1 ± 12.3 s; P < 0.001), and τP0.1 (57.4 ± 15.4 and 61.0 ± 12.9 s, respectively; P < 0.001) than adults. In hypoxia, children exhibited shorter τP0.1/VT/Ti compare to adults. Reinforced by the significant correlation between τ  V˙E and τP0.1/VT/Ti for children but not adults, we concluded that ventilatory response differences could be due in part to the respiratory system impedance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 161, Issue 3, 31 May 2008, Pages 239–245
نویسندگان
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