کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2848025 1571347 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gestational cigarette smoke exposure and hyperthermic enhancement of laryngeal chemoreflex in rat pups
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Gestational cigarette smoke exposure and hyperthermic enhancement of laryngeal chemoreflex in rat pups
چکیده انگلیسی

Laryngeal chemoreflex (LCR) apnea occurs in infant mammals of many species in response to water or other liquids in the laryngeal lumen. The apnea can last for many seconds, sometimes leading to dangerous hypoxemia, and has therefore been considered as a possible mechanism in the Sudden Infant Death Syndrome (SIDS). We have found recently that this reflex is markedly prolonged in decerebrate piglets and anesthetized rat pups that are warmed 1–3 °C above their normal body temperatures. We intermittently exposed pregnant rats to cigarette smoke and examined the LCR in their four- to fifteen-day-old offspring under general anesthesia, with and without whole body warming. During warming, pups of gestationally smoke-exposed dams had significantly longer LCR-induced respiratory disruption than similarly warmed control pups. The results may be significant for the pathogenesis and/or prevention of SIDS as maternal cigarette smoking during human pregnancy and heat stress in infants are known risk factors for SIDS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 165, Issues 2–3, 28 February 2009, Pages 161–166
نویسندگان
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