The structure and function of carbonic anhydrase isozymes in the respiratory system of vertebrates

Carbonic anhydrase is a ubiquitous metalloenzyme that catalyzes the reversible hydration/dehydration of carbon dioxide. To date, 16 different CA isozymes have been identified in mammals, and several novel isozymes have also been identified in non-mammalian vertebrates. These isozymes are involved in many physiological processes; however, one of the most important roles is facilitating the transport and subsequent excretion of carbon dioxide. As such, CA isozymes are found at virtually every step of the process, including the metabolic site of CO2 production (muscle), the circulating red blood cells, and the primary respiratory surface (gills/lungs). This review will examine the structural characteristics that are integral to CAs participation in respiration, as well as highlight the specific roles and tissues that the different CA isozymes are involved in.