کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2867921 | 1573586 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
En el origen de la enfermedad arterial periférica: papel de la endotelina en la disfunción endotelial
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کلمات کلیدی
Disfunción endotelial - اختلال اندوتلیالEndothelial dysfunction - اختلال عملکرد اندوتلیالInflamación - التهابinflammation - التهاب( توروم) endothelin - اندوتلینendotelina - اندوتلینIschaemia - ایسکمیIsquemia - ایسکمیPeripheral arterial disease - بیماری شریانی محیطیenfermedad arterial periférica - بیماری شریانی محیطیClaudicación intermitente - لرزش متناوبIntermittent claudication - لنگش متناوب
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: En el origen de la enfermedad arterial periférica: papel de la endotelina en la disfunción endotelial En el origen de la enfermedad arterial periférica: papel de la endotelina en la disfunción endotelial](/preview/png/2867921.png)
چکیده انگلیسی
Introduction. The aetiopathogenesis of arteriosclerosis includes a series of conditioning factors and chronic inflammatory processes that give rise to a permanent state of endothelial dysfunction. Endothelin (ET) is a protein that is involved in the functioning of endothelial cells and which seems to play a role in peripheral arterial disease (PAD), as a manifestation of arteriosclerosis. Aim. To examine the role of ET in PAD and its relation with the symptoms, endothelial functioning and inflammatory processes. Subjects and methods. We conducted a cross-sectional study with 141 subjects: 66 patients with intermittent claudication, 37 patients with critical ischaemia and 38 healthy controls. We measured the levels of ET and C-reactive protein (hsCRP) in plasma and the brachial artery flow-mediated dilation (BAFMD) in these three groups. Results. ET concentrations are significantly higher in patients than in healthy controls (8.76 ± 7.1 vs. 6.45 ± 0.89 pM/L; p = 0.002). Patients with claudication show significantly higher ET concentrations than patients with critical ischaemia (10.97 ± 7.9 vs. 4.82 ± 2.57 pM/L; p < 0.001). Patients with critical ischaemia had higher hsCRP values than those with claudication (16.94 vs. 4.73 mg/L; p = 0.001). No significant differences were observed in the BAFMD in the two groups (5.4 ± 3.7% in those with claudication, 5.85 ± 4.35%; p = 0.58). ET concentrations show a slight negative correlation with the hsCRP values (â 0.165; p = 0.095). Conclusions. Plasma concentrations of ET in patients with PAD are higher in the early stages of the disease. As the disease progresses, the ET values diminish while the inflammatory marker hsCRP increases. [ANGIOLOGIA 2008; 60: 395-401]
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: AngiologÃa - Volume 60, Issue 6, 2008, Pages 395-401
Journal: AngiologÃa - Volume 60, Issue 6, 2008, Pages 395-401
نویسندگان
A. Flórez-González, J. de Haro-Miralles, C. Varela-Casariego, F. AcÃn,