Metaloproteinasas de matriz: su implicación en las enfermedades vasculares periféricas

Owing to their capacity to degrade the components of the extracellular matrix, MMPs are enzymes that play an important role in numerous biological and pathological processes, including some vascular diseases. The progress being made in our understanding of its mechanisms of action, substrate specificity and the mechanisms of inhibition used by the tissue inhibitors of MMPs has enabled us to design synthetic metalloprotease inhibitors that will probably make it possible in the future to design new therapeutic strategies with which to fight these diseases.