Upregulation of Nuclear Heat Shock Factor 1 Contributes to Tumor Angiogenesis and Poor Survival in Patients With Non-Small Cell Lung Cancer

Overexpression of HSF1 is common and significantly correlated with tumor angiogenesis in NSCLC. Patients with high HSF1 expression had poorer overall, disease-free, and disease-specific survival. These current findings suggest that HSF1 may serve as a novel prognostic marker and potential therapeutic target molecule for antiangiogenic therapy in patients with NSCLC.